If you have been looking to upgrade your healing potion to a Strong Healing Potion at the Alchemist in Diablo 4, then you have likely needed to find Paletongue. This disgusting crafting material is said to only be found “in the mouths of evil humans,” which doesn’t give players a great idea of where to start looking for it.
Like most other magic crafting materials in Diablo 4, Paletongue can be found naturally by simply playing through the main story. Eventually, a boss or other monster will drop a Paletongue for you to pick up.
If you want to find Paletongue and find it fast, then you will need some guaranteed drops for it. Here’s the best farming method for Paletongue in Sanctuary.
Getting Paletongue in Diablo 4

The easiest farming method I found for Paletongue takes place in the region of Dry Steppes. On the very western side of this region, you will find a rare enemy by the name of Alumn. Alumn is a demon that drops one Paletongue, Demon’s Heart, and Grave Dust upon its death.
If you kill the enemy, then leave the area by fast traveling and return to its location, Alumn will spawn again, allowing you to repeat the process over. Within just 20 minutes, you should have enough Paletongue to either upgrade your healing potion or craft a certain elixir.

In addition to Alumn, I found that going through the region of Scosglen was the best natural source for Paletongue. There are hundreds of cultists in this region, and they qualify as evil humans, meaning they have a chance to drop the material. Of course, it’s still a rare chance for this to happen, so don’t take killing cultists as a guaranteed way to loot Paletongue.
Once you have enough Paletongue for your needs, you can head to the Alchemist, craft your new potion or elixir, and be on your way in Diablo 4.